Browsing ICR Research Publications by Series "Methods in Molecular Biology"

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    • Generation of induced pluripotent stem cells from mammalian endangered species
      Ben-Nun, Inbar Friedrich; Montague, Susanne C.; Houck, Marlys L.; Ryder, Oliver A.; Loring, Jeanne F.; Verma P.; Sumer H. (Humana PressNew York, NY, 2015)
      For some highly endangered species there are too few reproductively capable animals to maintain adequate genetic diversity, and extraordinary measures are necessary to prevent their extinction. Cellular reprogramming is a means to capture the genomes of individual animals as induced pluripotent stem cells (iPSCs), which may eventually facilitate reintroduction of genetic material into breeding populations. Here, we describe a method for generating iPSCs from fibroblasts of mammalian endangered species.