• Copy number variation analysis in the great apes reveals species-specific patterns of structural variation

      Gazave, E.; Darre, F.; Morcillo-Suarez, C.; Petit-Marty, N.; Carreno, A.; Marigorta, U. M.; Ryder, Oliver A.; Blancher, A.; Rocchi, M.; Bosch, E.; et al. (2011)
      ...We performed intraspecific comparative genomic hybridizations to identify loci harboring copy number variants in each of the four great apes: bonobos, chimpanzees, gorillas, and orangutans. For the first time, we could analyze differences in CNV location and frequency in these four species, and compare them with human CNVs and primate segmental duplication (SD) maps....
    • Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions

      Watkins, Paul A.; Moser, Ann B.; Toomer, Cicely B.; Steinberg, Steven J.; Moser, Hugo W.; Karaman, Mazen W.; Ramaswamy, Krishna; Siegmund, Kimberly D.; Lee, D. Rick; Ely, John J.; et al. (2010)
      It has been proposed that anatomical differences in human and great ape guts arose in response to species-specific diets and energy demands. To investigate functional genomic consequences of these differences, we compared their physiological levels of phytanic acid, a branched chain fatty acid that can be derived from the microbial degradation of chlorophyll in ruminant guts. Humans who accumulate large stores of phytanic acid commonly develop cerebellar ataxia, peripheral polyneuropathy, and retinitis pigmentosa in addition to other medical conditions. Furthermore, phytanic acid is an activator of the PPAR-alpha transcription factor that influences the expression of genes relevant to lipid metabolism.
    • Recent decline in suitable environmental conditions for African great apes

      Junker, Jessica; Blake, Stephen; Boesch, Christophe; Campbell, Geneviève; Toit, Louwrens du; Duvall, Chris; Ekobo, Atanga; Etoga, Gilles; Galat-Luong, Anh; Gamys, Joel; et al. (2012)
      To predict the distribution of suitable environmental conditions (SEC) for eight African great ape taxa for a first time period, the 1990s and then project it to a second time period, the 2000s; to assess the relative importance of factors influencing SEC distribution and to estimate rates of SEC loss, isolation and fragmentation over the last two decades....
    • Regurgitation and reingestion in bonobos (Pan paniscus): Relationships between abnormal and social behavior

      Miller, Lance J.; Tobey, Jennifer R. (2012)
      Regurgitation and reingestion (R/R) is an abnormal behavior observed in great apes analogous to rumination syndrome in humans….The purpose of the current study was to examine R/R in 14 bonobos (Pan paniscus) at two zoological institutions. This included examining the relationships between R/R and other bonobo behaviors as well as the effect of a change in social groupings on R/R….