• Hormones and reproductive cycles in Crocodilians

      Milnes, Matthew R.; Norris, D.O.; Lopez, K.H. (ElsevierSan Diego, CA, 2011)
      During embryonic development, hormonal influence upon sexual differentiation in crocodilians begins and continues for years until sexual maturation is attained. Shortly after sex determination, estrogen production in the embryonic ovary increases and promotes proliferation of the Müsllerian ducts, whereas the testis produces anti-Müllerian hormone, which results in its regression....
    • Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF

      Ruggeri, Elena; Lira-Albarrán, Saúl; Grow, Edward J; Liu, Xiaowei; Harner, Royce; Maltepe, Emin; Ramalho-Santos, Miguel; Donjacour, Annemarie; Rinaudo, Paolo (2020)
      …Animal studies indicate that IVF offspring display metabolic alterations, including hypertension, glucose intolerance and cardiac hypertrophy, often in a sexual dimorphic fashion. The detailed nature of epigenetic changes following in-vitro culture is, however, unknown. This study was performed to evaluate the epigenetic (using whole-genome bisulfite sequencing (WGBS) and assay for transposase-accessible chromatin using sequencing (ATAC-seq)) and transcriptomic changes (using RNA-seq) occurring in the inner cell mass (ICM) of male or female mouse embryos generated in vivo or by IVF....