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dc.contributor.authorWisely, S. M.
dc.contributor.authorRyder, Oliver A.
dc.contributor.authorSantymire, R. M.
dc.contributor.authorEngelhardt, J. F.
dc.contributor.authorNovak, B. J.
dc.date.accessioned2020-06-29T18:08:55Z
dc.date.available2020-06-29T18:08:55Z
dc.date.issued2015
dc.identifier.issn0022-1503
dc.identifier.doi10.1093/jhered/esv041
dc.identifier.urihttp://hdl.handle.net/20.500.12634/466
dc.description.abstractInterspecies somatic cell nuclear transfer (iSCNT) could benefit recovery programs of critically endangered species but must be weighed with the risks of failure. To weigh the risks and benefits, a decision-making process that evaluates progress is needed. Experiments that evaluate the efficiency and efficacy of blastocyst, fetal, and post-parturition development are necessary to determine the success or failure or species-specific iSCNT programs. Here, we use the black-footed ferret (Mustela nigripes) as a case study for evaluating this emerging biomedical technology as a tool for genetic restoration. The black-footed ferret has depleted genetic variation yet genome resource banks contain genetic material of individuals not currently represented in the extant lineage. Thus, genetic restoration of the species is in theory possible and could help reduce the persistent erosion of genetic diversity from drift. Extensive genetic, genomic, and reproductive science tools have previously been developed in black-footed ferrets and would aid in the process of developing an iSCNT protocol for this species. Nonetheless, developing reproductive cloning will require years of experiments and a coordinated effort among recovery partners. The information gained from a well-planned research effort with the goal of genetic restoration via reproductive cloning could establish a 21st century model for evaluating and implementing conservation breeding that would be applicable to other genetically impoverished species.
dc.language.isoen
dc.relation.urlhttps://academic.oup.com/jhered/article/106/5/581/2961879/A-Road-Map-for-21st-Century-Genetic-Restoration
dc.rights© The American Genetic Association. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttp://creativecommons.org/licenses/ by/3.0/
dc.subjectFERRETS
dc.subjectCONSERVATION
dc.subjectPOPULATION GENETICS
dc.subjectWILDLIFE CONSERVATION
dc.titleA road map for 21st century genetic restoration: Gene pool enrichment of the black-footed ferret
dc.typeArticle
dc.source.journaltitleJournal of Heredity
dc.source.volume106
dc.source.issue5
dc.source.beginpage581
dc.source.endpage592
refterms.dateFOA2020-06-29T18:08:55Z
html.description.abstractInterspecies somatic cell nuclear transfer (iSCNT) could benefit recovery programs of critically endangered species but must be weighed with the risks of failure. To weigh the risks and benefits, a decision-making process that evaluates progress is needed. Experiments that evaluate the efficiency and efficacy of blastocyst, fetal, and post-parturition development are necessary to determine the success or failure or species-specific iSCNT programs. Here, we use the black-footed ferret (Mustela nigripes) as a case study for evaluating this emerging biomedical technology as a tool for genetic restoration. The black-footed ferret has depleted genetic variation yet genome resource banks contain genetic material of individuals not currently represented in the extant lineage. Thus, genetic restoration of the species is in theory possible and could help reduce the persistent erosion of genetic diversity from drift. Extensive genetic, genomic, and reproductive science tools have previously been developed in black-footed ferrets and would aid in the process of developing an iSCNT protocol for this species. Nonetheless, developing reproductive cloning will require years of experiments and a coordinated effort among recovery partners. The information gained from a well-planned research effort with the goal of genetic restoration via reproductive cloning could establish a 21st century model for evaluating and implementing conservation breeding that would be applicable to other genetically impoverished species.


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© The American Genetic Association. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as © The American Genetic Association. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.