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Date Issued
2013Author
Prado-Martinez, JavierSudmant, Peter H.
Kidd, Jeffrey M.
Li, Heng
Kelley, Joanna L.
Lorente-Galdos, Belen
Veeramah, Krishna R.
Woerner, August E.
O’Connor, Timothy D.
Santpere, Gabriel
Cagan, Alexander
Theunert, Christoph
Casals, Ferran
Laayouni, Hafid
Munch, Kasper
Hobolth, Asger
Halager, Anders E.
Malig, Maika
Hernandez-Rodriguez, Jessica
Hernando-Herraez, Irene
Prüfer, Kay
Pybus, Marc
Johnstone, Laurel
Lachmann, Michael
Alkan, Can
Twigg, Dorina
Petit, Natalia
Baker, Carl
Hormozdiari, Fereydoun
Fernandez-Callejo, Marcos
Dabad, Marc
Wilson, Michael L.
Stevison, Laurie
Camprubí, Cristina
Carvalho, Tiago
Ruiz-Herrera, Aurora
Vives, Laura
Mele, Marta
Abello, Teresa
Kondova, Ivanela
Bontrop, Ronald E.
Pusey, Anne
Lankester, Felix
Kiyang, John A.
Bergl, Richard A.
Lonsdorf, Elizabeth
Myers, Simon
Ventura, Mario
Gagneux, Pascal
Comas, David
Siegismund, Hans
Blanc, Julie
Agueda-Calpena, Lidia
Gut, Marta
Fulton, Lucinda
Tishkoff, Sarah A.
Mullikin, James C.
Wilson, Richard K.
Gut, Ivo G.
Gonder, Mary Katherine
Ryder, Oliver A.
Hahn, Beatrice H.
Navarro, Arcadi
Akey, Joshua M.
Bertranpetit, Jaume
Reich, David
Mailund, Thomas
Schierup, Mikkel H.
Hvilsom, Christina
Andrés, Aida M.
Wall, Jeffrey D.
Bustamante, Carlos D.
Hammer, Michael F.
Eichler, Evan E.
Marques-Bonet, Tomas
Subject Terms
APESCHIMPANZEES
GORILLAS
ORANGUTANS
BONOBOS
HUMANS
GENOMICS
INBREEDING
EVOLUTION
POPULATION GENETICS
AFRICA
SOUTHEAST ASIA
Journal
NatureVolume
499Issue
7459Start page
471End page
475
Metadata
Show full item recordAlternative link
https://www.nature.com/articles/nature12228Abstract
Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape species and seven subspecies and report 88.8 million single nucleotide polymorphisms. Our analysis provides support for genetically distinct populations within each species, signals of gene flow, and the split of common chimpanzees into two distinct groups: Nigeria–Cameroon/western and central/eastern populations. We find extensive inbreeding in almost all wild populations, with eastern gorillas being the most extreme. Inferred effective population sizes have varied radically over time in different lineages and this appears to have a profound effect on the genetic diversity at, or close to, genes in almost all species. We discover and assign 1,982 loss-of-function variants throughout the human and great ape lineages, determining that the rate of gene loss has not been different in the human branch compared to other internal branches in the great ape phylogeny. This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations.Type
ArticleRights
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported licence. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-sa/3.0ae974a485f413a2113503eed53cd6c53
10.1038/nature12228
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Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported licence. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-sa/3.0