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dc.contributor.authorPrado-Martinez, Javier
dc.contributor.authorSudmant, Peter H.
dc.contributor.authorKidd, Jeffrey M.
dc.contributor.authorLi, Heng
dc.contributor.authorKelley, Joanna L.
dc.contributor.authorLorente-Galdos, Belen
dc.contributor.authorVeeramah, Krishna R.
dc.contributor.authorWoerner, August E.
dc.contributor.authorO’Connor, Timothy D.
dc.contributor.authorSantpere, Gabriel
dc.contributor.authorCagan, Alexander
dc.contributor.authorTheunert, Christoph
dc.contributor.authorCasals, Ferran
dc.contributor.authorLaayouni, Hafid
dc.contributor.authorMunch, Kasper
dc.contributor.authorHobolth, Asger
dc.contributor.authorHalager, Anders E.
dc.contributor.authorMalig, Maika
dc.contributor.authorHernandez-Rodriguez, Jessica
dc.contributor.authorHernando-Herraez, Irene
dc.contributor.authorPrüfer, Kay
dc.contributor.authorPybus, Marc
dc.contributor.authorJohnstone, Laurel
dc.contributor.authorLachmann, Michael
dc.contributor.authorAlkan, Can
dc.contributor.authorTwigg, Dorina
dc.contributor.authorPetit, Natalia
dc.contributor.authorBaker, Carl
dc.contributor.authorHormozdiari, Fereydoun
dc.contributor.authorFernandez-Callejo, Marcos
dc.contributor.authorDabad, Marc
dc.contributor.authorWilson, Michael L.
dc.contributor.authorStevison, Laurie
dc.contributor.authorCamprubí, Cristina
dc.contributor.authorCarvalho, Tiago
dc.contributor.authorRuiz-Herrera, Aurora
dc.contributor.authorVives, Laura
dc.contributor.authorMele, Marta
dc.contributor.authorAbello, Teresa
dc.contributor.authorKondova, Ivanela
dc.contributor.authorBontrop, Ronald E.
dc.contributor.authorPusey, Anne
dc.contributor.authorLankester, Felix
dc.contributor.authorKiyang, John A.
dc.contributor.authorBergl, Richard A.
dc.contributor.authorLonsdorf, Elizabeth
dc.contributor.authorMyers, Simon
dc.contributor.authorVentura, Mario
dc.contributor.authorGagneux, Pascal
dc.contributor.authorComas, David
dc.contributor.authorSiegismund, Hans
dc.contributor.authorBlanc, Julie
dc.contributor.authorAgueda-Calpena, Lidia
dc.contributor.authorGut, Marta
dc.contributor.authorFulton, Lucinda
dc.contributor.authorTishkoff, Sarah A.
dc.contributor.authorMullikin, James C.
dc.contributor.authorWilson, Richard K.
dc.contributor.authorGut, Ivo G.
dc.contributor.authorGonder, Mary Katherine
dc.contributor.authorRyder, Oliver A.
dc.contributor.authorHahn, Beatrice H.
dc.contributor.authorNavarro, Arcadi
dc.contributor.authorAkey, Joshua M.
dc.contributor.authorBertranpetit, Jaume
dc.contributor.authorReich, David
dc.contributor.authorMailund, Thomas
dc.contributor.authorSchierup, Mikkel H.
dc.contributor.authorHvilsom, Christina
dc.contributor.authorAndrés, Aida M.
dc.contributor.authorWall, Jeffrey D.
dc.contributor.authorBustamante, Carlos D.
dc.contributor.authorHammer, Michael F.
dc.contributor.authorEichler, Evan E.
dc.contributor.authorMarques-Bonet, Tomas
dc.date.accessioned2020-08-28T21:03:01Z
dc.date.available2020-08-28T21:03:01Z
dc.date.issued2013
dc.identifier.issn1476-4687
dc.identifier.doi10.1038/nature12228
dc.identifier.urihttp://hdl.handle.net/20.500.12634/654
dc.description.abstractMost great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape species and seven subspecies and report 88.8 million single nucleotide polymorphisms. Our analysis provides support for genetically distinct populations within each species, signals of gene flow, and the split of common chimpanzees into two distinct groups: Nigeria–Cameroon/western and central/eastern populations. We find extensive inbreeding in almost all wild populations, with eastern gorillas being the most extreme. Inferred effective population sizes have varied radically over time in different lineages and this appears to have a profound effect on the genetic diversity at, or close to, genes in almost all species. We discover and assign 1,982 loss-of-function variants throughout the human and great ape lineages, determining that the rate of gene loss has not been different in the human branch compared to other internal branches in the great ape phylogeny. This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations.
dc.language.isoen
dc.relation.urlhttps://www.nature.com/articles/nature12228
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported licence. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-sa/3.0
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0
dc.subjectAPES
dc.subjectCHIMPANZEES
dc.subjectGORILLAS
dc.subjectORANGUTANS
dc.subjectBONOBOS
dc.subjectHUMANS
dc.subjectGENOMICS
dc.subjectINBREEDING
dc.subjectEVOLUTION
dc.subjectPOPULATION GENETICS
dc.subjectAFRICA
dc.subjectSOUTHEAST ASIA
dc.titleGreat ape genetic diversity and population history
dc.typeArticle
dc.source.journaltitleNature
dc.source.volume499
dc.source.issue7459
dc.source.beginpage471
dc.source.endpage475
refterms.dateFOA2020-08-28T21:03:01Z
html.description.abstractMost great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape species and seven subspecies and report 88.8 million single nucleotide polymorphisms. Our analysis provides support for genetically distinct populations within each species, signals of gene flow, and the split of common chimpanzees into two distinct groups: Nigeria–Cameroon/western and central/eastern populations. We find extensive inbreeding in almost all wild populations, with eastern gorillas being the most extreme. Inferred effective population sizes have varied radically over time in different lineages and this appears to have a profound effect on the genetic diversity at, or close to, genes in almost all species. We discover and assign 1,982 loss-of-function variants throughout the human and great ape lineages, determining that the rate of gene loss has not been different in the human branch compared to other internal branches in the great ape phylogeny. This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations.


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This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported licence. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-sa/3.0
Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported licence. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-sa/3.0