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dc.contributor.authorHouck, Marlys L.
dc.contributor.editorLoring, Jeanne F.
dc.contributor.editorPeterson, Suzanne E.
dc.date.accessioned2020-11-06T21:36:34Z
dc.date.available2020-11-06T21:36:34Z
dc.date.issued2012
dc.identifier.isbn978-0-12-385473-5
dc.identifier.doi10.1016/B978-0-12-385473-5.00013-8
dc.identifier.urihttp://hdl.handle.net/20.500.12634/725
dc.description.abstractHuman pluripotent stem cells (hPSCs) are arguably the most stable normal diploid cells that can be maintained in long-term culture. However, aneuploidies and other chromosomal abnormalities do occur with time in culture. Aneuploidy in mouse ESC lines invariably results in their failure to contribute to the germline in chimeric animals. But since this ultimate test of normalcy cannot be applied to human PSCs, the cultures must be routinely evaluated for chromosomal abnormalities....
dc.language.isoen
dc.publisherElsevier
dc.relation.urihttp://linkinghub.elsevier.com/retrieve/pii/B9780123854735000138
dc.rightsCopyright © 2012 Elsevier Inc. All rights reserved.
dc.subjectSTEM CELLS
dc.subjectCELL CULTURE
dc.subjectCYTOLOGY
dc.titleClassical cytogenetics: Karyotyping
dc.typeBook Chapter
dc.source.journaltitleHuman Stem Cell Manual: A Laboratory Guide
dc.source.beginpage187
dc.source.endpage202
html.description.abstractHuman pluripotent stem cells (hPSCs) are arguably the most stable normal diploid cells that can be maintained in long-term culture. However, aneuploidies and other chromosomal abnormalities do occur with time in culture. Aneuploidy in mouse ESC lines invariably results in their failure to contribute to the germline in chimeric animals. But since this ultimate test of normalcy cannot be applied to human PSCs, the cultures must be routinely evaluated for chromosomal abnormalities....
dc.publisher.locationLondon


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  • SDZWA Research Publications
    Peer reviewed and scientific works by San Diego Zoo Wildlife Alliance staff. Includes books, book sections, articles and conference publications and presentations.

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