Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2019Author
Chen, LeiQiu, Qiang
Jiang, Yu
Wang, Kun
Lin, Zeshan
Li, Zhipeng
Bibi, Faysal
Yang, Yongzhi
Wang, Jinhuan
Nie, Wenhui
Su, Weiting
Liu, Guichun
Li, Qiye
Fu, Weiwei
Pan, Xiangyu
Liu, Chang
Yang, Jie
Zhang, Chenzhou
Yin, Yuan
Wang, Yu
Zhao, Yue
Zhang, Chen
Wang, Zhongkai
Qin, Yanli
Liu, Wei
Wang, Bao
Ren, Yandong
Zhang, Ru
Zeng, Yan
da Fonseca, Rute R.
Wei, Bin
Li, Ran
Wan, Wenting
Zhao, Ruoping
Zhu, Wenbo
Wang, Yutao
Duan, Shengchang
Gao, Yun
Zhang, Yong E.
Chen, Chunyan
Hvilsom, Christina
Epps, Clinton W.
Chemnick, Leona G.
Dong, Yang
Mirarab, Siavash
Siegismund, Hans Redlef
Ryder, Oliver A.
Gilbert, M. Thomas P.
Lewin, Harris A.
Zhang, Guojie
Heller, Rasmus
Wang, Wen
Journal title
ScienceVolume
364Issue
6446Begin page
eaav6202
Metadata
Show full item recordAlternative link
http://www.sciencemag.org/lookup/doi/10.1126/science.aav6202Abstract
The ruminants are one of the most successful mammalian lineages, exhibiting morphological and habitat diversity and containing several key livestock species. To better understand their evolution, we generated and analyzed de novo assembled genomes of 44 ruminant species, representing all six Ruminantia families....Type
ArticleRights
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.Rights link
http://www.sciencemag.org/about/science-licenses-journal-article-reuseae974a485f413a2113503eed53cd6c53
10.1126/science.aav6202
Scopus Count
Collections
Related items
Showing items related by title, author, creator and subject.
-
Comparative genomics reveals insights into avian genome evolution and adaptationZhang, Guojie; Li, Cai; Li, Qiye; Li, Bo; Larkin, Denis M.; Lee, Chul; Storz, Jay F.; Antunes, Agostinho; Greenwold, Matthew J.; Meredith, Robert W.; et al. (2014)Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades....
-
The value of ecosystem services from giant panda reservesWei, Fuwen; Costanza, Robert; Dai, Qiang; Stoeckl, Natalie; Gu, Xiaodong; Farber, Stephen; Nie, Yonggang; Kubiszewski, Ida; Hu, Yibo; Swaisgood, Ronald R.; et al. (2018)Ecosystem services (the benefits to humans from ecosystems) are estimated globally at $125 trillion/year [1, 2]. Similar assessments at national and regional scales show how these services support our lives [3]. All valuations recognize the role of biodiversity, which continues to decrease around the world in maintaining these services [4, 5]....
-
Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptationYu, Li; Wang, Guo-Dong; Ruan, Jue; Chen, Yong-Bin; Yang, Cui-Ping; Cao, Xue; Wu, Hong; Liu, Yan-Hu; Du, Zheng-Lin; Wang, Xiao-Ping; et al. (2016)The snub-nosed monkey genus Rhinopithecus includes five closely related species distributed across altitudinal gradients from 800 to 4,500 m. Rhinopithecus bieti, Rhinopithecus roxellana, and Rhinopithecus strykeri inhabit high-altitude habitats, whereas Rhinopithecus brelichi and Rhinopithecus avunculus inhabit lowland regions. We report the de novo whole-genome sequence of R. bieti and genomic sequences for the four other species. Eight shared substitutions were found in six genes related to lung function, DNA repair, and angiogenesis in the high-altitude snub-nosed monkeys. Functional assays showed that the high-altitude variant of CDT1 (Ala537Val) renders cells more resistant to UV irradiation, and the high-altitude variants of RNASE4 (Asn89Lys and Thr128Ile) confer enhanced ability to induce endothelial tube formation in vitro. Genomic scans in the R. bieti and R. roxellana populations identified signatures of selection between and within populations at genes involved in functions relevant to high-altitude adaptation. These results provide valuable insights into the adaptation to high altitude in the snub-nosed monkeys.