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A comparative genomics multitool for scientific discovery and conservation

dc.contributor.authorGenereux, Diane P.
dc.contributor.authorSerres, Aitor
dc.contributor.authorArmstrong, Joel
dc.contributor.authorJohnson, Jeremy
dc.contributor.authorMarinescu, Voichita D.
dc.contributor.authorMurén, Eva
dc.contributor.authorJuan, David
dc.contributor.authorBejerano, Gill
dc.contributor.authorCasewell, Nicholas R.
dc.contributor.authorChemnick, Leona G.
dc.contributor.authorDamas, Joana
dc.contributor.authorDi Palma, Federica
dc.contributor.authorDiekhans, Mark
dc.contributor.authorFiddes, Ian T.
dc.contributor.authorGarber, Manuel
dc.contributor.authorGladyshev, Vadim N.
dc.contributor.authorGoodman, Linda
dc.contributor.authorHaerty, Wilfried
dc.contributor.authorHouck, Marlys L.
dc.contributor.authorHubley, Robert
dc.contributor.authorKivioja, Teemu
dc.contributor.authorKoepfli, Klaus-Peter
dc.contributor.authorKuderna, Lukas F. K.
dc.contributor.authorLander, Eric S.
dc.contributor.authorMeadows, Jennifer R. S.
dc.contributor.authorMurphy, William J.
dc.contributor.authorNash, Will
dc.contributor.authorNoh, Hyun Ji
dc.contributor.authorNweeia, Martin
dc.contributor.authorPfenning, Andreas R.
dc.contributor.authorPollard, Katherine S.
dc.contributor.authorRay, David A.
dc.contributor.authorShapiro, Beth
dc.contributor.authorSmit, Arian F. A.
dc.contributor.authorSpringer, Mark S.
dc.contributor.authorSteiner, Cynthia C.
dc.contributor.authorSwofford, Ross
dc.contributor.authorTaipale, Jussi
dc.contributor.authorTeeling, Emma C.
dc.contributor.authorTurner-Maier, Jason
dc.contributor.authorAlfoldi, Jessica
dc.contributor.authorBirren, Bruce
dc.contributor.authorRyder, Oliver A.
dc.contributor.authorLewin, Harris A.
dc.contributor.authorPaten, Benedict
dc.contributor.authorMarques-Bonet, Tomas
dc.contributor.authorLindblad-Toh, Kerstin
dc.contributor.authorKarlsson, Elinor K.
dc.contributor.authorZoonomia Consortium
dc.date.accessioned2020-12-23T19:19:20Z
dc.date.available2020-12-23T19:19:20Z
dc.date.issued2020
dc.identifier.issn1476-4687
dc.identifier.doi10.1038/s41586-020-2876-6
dc.identifier.urihttp://hdl.handle.net/20.500.12634/808
dc.description.abstractThe Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
dc.language.isoen
dc.relation.urlhttps://www.nature.com/articles/s41586-020-2876-6
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGENOMICS
dc.subjectRESEARCH
dc.subjectFROZEN ZOO
dc.subjectSAN DIEGO ZOO
dc.subjectEVOLUTION
dc.subjectBIODIVERSITY
dc.subjectDATA PROCESSING
dc.subjectMAMMALS
dc.titleA comparative genomics multitool for scientific discovery and conservation
dc.typeArticle
dc.source.journaltitleNature
dc.source.volume587
dc.source.issue7833
dc.source.beginpage240
dc.source.endpage245
dcterms.dateAccepted2020
refterms.dateFOA2021-01-14T22:48:47Z
html.description.abstractThe Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.


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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.