Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination: The comparative biology of mammalian telomeres
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Issue Date
2011Author
Gomes, Nuno M. V.Ryder, Oliver A.
Houck, Marlys L.
Charter, Suellen J.
Walker, William
Forsyth, Nicholas R.
Austad, Steven N.
Venditti, Chris
Pagel, Mark
Shay, Jerry W.
Wright, Woodring E.
Journal title
Aging CellVolume
10Issue
5Begin page
761End page
768
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http://doi.wiley.com/10.1111/j.1474-9726.2011.00718.xAbstract
...We examined telomeres/telomerase in cultured cells from >?60 mammalian species to place different uses of telomeres in a broad mammalian context. Phylogeny?based statistical analysis reconstructed ancestral states. Our analysis suggested that the ancestral mammalian phenotype included short telomeres (20?kb, as we now see in humans) and repressed telomerase.....Type
ArticleRights
© 2011 The Authors. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Irelandae974a485f413a2113503eed53cd6c53
10.1111/j.1474-9726.2011.00718.x
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