Rewinding extinction in the northern white rhinoceros: Genetically diverse induced pluripotent stem cell bank for genetic rescue
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Date Issued
2021Author
Korody, Marisa L.Ford, Sarah M.
Nguyen, Thomas D.
Pivaroff, Cullen G.
Valiente-Alandi, Iñigo
Peterson, Suzanne E.
Ryder, Oliver A.
Loring, Jeanne F.
Subject Terms
ENDANGERED SPECIESCONSERVATION
FROZEN ZOO
WHITE RHINOCEROSES
RESEARCH
EXTINCTION
STEM CELLS
Journal
Stem Cells and DevelopmentVolume
30Issue
4Start page
177End page
177
Metadata
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https://www.liebertpub.com/doi/abs/10.1089/scd.2021.0001Abstract
Extinction rates are rising, and current conservation technologies may not be adequate for reducing species losses. Future conservation efforts may be aided by the generation of induced pluripotent stem cells (iPSCs) from highly endangered species. Generation of a set of iPSCs from multiple members of a species can capture some of the dwindling genetic diversity of a disappearing species. We generated iPSCs from fibroblasts cryopreserved in the Frozen Zoo: nine genetically diverse individuals of the functionally extinct northern white rhinoceros (Ceratotherium simum cottoni) and two from the closely related southern white rhinoceros (Ceratotherium simum simum). We used a non-integrating Sendai virus reprogramming method and developed analyses to confirm the cells’ pluripotency and differentiation potential. This work is the first step of a long-term interdisciplinary plan to apply assisted reproduction techniques to the conservation of this highly endangered species. Advances in iPSC differentiation may enable generation of gametes in vitro from deceased and non-reproductive individuals that could be used to repopulate the species.Type
ArticleRights
© Marisa L. Korody et al. 2021; 1; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.ae974a485f413a2113503eed53cd6c53
10.1089/scd.2021.0001
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Except where otherwise noted, this item's license is described as © Marisa L. Korody et al. 2021; 1; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the
Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.